Analysis Note

To view the Certificate of Analysis for this product, please visit www.cytiva.com.

Features and Benefits

Withstands rigorous CIP and sanitization procedures with 0.1 to 0.5 M NaOH. Novel ligand design gives enhanced protease resistance resulting in lower ligand leakage. Oriented coupling of recombinant Protein A to the matrix via an engineered C-terminal cysteine enhances IgG binding capacity. Fewer regulatory concerns due to the total absence of mammalian culture in the ligand production and purification. Prepacked HiTrap^® columns for process development, screening of purification conditions, and small-scale purification of Mabs.

General description

HiTrap^® MabSelect^™ SuRe^™ columns are prepacked with MabSelect^™ SuRe, a BioProcess medium for purification of monoclonal antibodies from large sample volumes. The novel alkali-tolerant recombinant Protein A ligand allow cleaning-in-place (CIP).HiTrap^® MabSelect^™ columns are prepacked with MabSelect^™ a bioprocess medium for capuring of Mabs from large sample volumes.

Legal Information

MabSelect SuRe is a trademark of Cytiva

SuRe is a trademark of Cytiva

Free MabSelect SuRe Ligand"MabSelect SuRe Ligand Restricted License" and "Cys-rProtein A Ligand Restricted License" are protected by the following patents and equivalent patents and patent applications in other countries: US 6,399,750 and EP 1123389. A free, non-transferable limited license to use this product for internal analytical purposes only accompanies the purchase of the product from a Cytiva company and its licensed distributors. Any other use will require a separate license from a Cytiva company.

MabSelect is a trademark of Cytiva

HiTrap is a registered trademark of Cytiva

avg. part. size	85 µm (d??v is the median particle size of the cumulative volume distribution)
bed size	16 mm × 25 mm
bed volume	5 mL
capacity	≥30 mg binding capacity (humanlgG/ml at 2.4 min residence time)(Determined at 10% breakthrough by frontal analysis at a mobile phase velocity of 500 cm/h in a column with a bed height of 20 cm.)
cleaning	2-13.7(pH below 3 is sometimes required to elute strongly bound IgG species. However, protein ligands may hydrolyze at very low pH.)
column I.D.	16 mm
manufacturer/tradename	Cytiva 11-0034-94
matrix	highly cross-linked agarose
packaging	pack of 1 × 5 mL
parameter	flow rate, ﹤20 ml/min flow rate (1)The pressure over the packed bed varies depending on a range of parameters such as the characteristics of the chromatography medium and the column tubing used.), 42 psi, ﹤20 mL/min flow rate (The pressure over the packed bed varies depending on a range of parameters such as the characteristics of the chromatography medium and the column tubing used.)
shelf life	Please be aware this product may be shipped 90 days before the expiration date. For more information on the batch specific expiration date, please contact technical service.
storage condition	(20% Ehtanol), (20% Ethanol)
storage temp.	2-8°C
suitability	suitable for bioprocess medium
working range	3-12(pH below 3 is sometimes required to elute strongly bound IgG species. However, protein ligands may hydrolyze at very low pH.)

Hazard Class	3
Un Number	1170
Pack Group	III

This product has met the following criteria to qualify for the following awards:

HiTrap MabSelect SuRe, Cytiva, 11-0034-94, pack of 1 x 5 mL

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